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| 3,4,5-三甲氧基苯甲醛的合成工艺改进 |
| Improvement of the Synthetic Process of 3,4,5-Trimethoxy Benzaldehyde |
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| DOI：10.3969/j.issn.1671-5322.2007.04.001 |
| 中文关键词: 3,4,5-三甲氧基苯甲醛 甲氧基化 甲基化 溴 回收 |
| 英文关键词: 3,4,5-trimethoxy benzaldehyde methoxylation methylation bromine reclaim |
| 基金项目: |
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| 摘要点击次数: 3987 |
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| 中文摘要: |
| 用对羟基苯甲醛与溴反应生成3,5-二溴-4-羟基苯甲醛和HBr, 3,5-二溴-4-羟基苯甲醛用氯化亚铜作催化剂,在DMF溶剂中与甲醇钠反应生成3,5-二甲氧基-4-羟基苯甲醛(丁香醛),丁香醛在pH=9用硫酸二甲酯甲基化得到3,4,5-三甲氧基苯甲醛.反应中生成的HBr和NaBr氧化成溴供循环使用. |
| 英文摘要: |
| P-hydroxy benzaldehyde reacts with bromine to form 3,5-bromo-4-hydroxy benzaldehyde,then fwthes reaction occurs with sodium methylate to obtain 3,5-methoxy-4-hydroxy benzaldehyde in the solution of DMF and employing cuprous chloride as catalyst.In the end,this compound is methylafed by bimethyl sulphade to synthesize 3,4,5-trimethoxy benzaldehyde at pH 9.The sodium bromine and hydrobromine in the reaction can circularly use. |
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