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| 基于金纳米作用适配体荧光探针的研究进展 |
| The Research Progress of Fluorescent Probes Based on the Interactions of Aptamer and Gold Nanoparticles |
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| DOI：10.3969/j.issn.1671-5322.2010.01.007 |
| 中文关键词: 适配体 金纳米颗粒 荧光探针 |
| 英文关键词: aptamer gold nanoparticles fluorescent probe |
| 基金项目:江苏省环保厅资助项目，盐城工学院校基金，江苏省大学生实践创新训练计划项目 |
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| 中文摘要: |
| 适配体是一类能与相应配体进行特异性结合的寡核苷酸序列,对靶分子具有高度亲和力和专一性的识别能力.作为新型的功能分子,它在化学领域、生命科学以及生物医学领域发展迅速,并展示了良好的应用前景.简要综述了基于金纳米作用适配体荧光探针的研究进展. |
| 英文摘要: |
| Aptamers are nucleic acide ligands isolated from combinatorial oligonucleotide libraries by in vitro selection,aptamers can bind to a great variety of molecular targets with high affinity and specific recognizability.As a new kind of functional molecular,aptamers have been rapid developed and broadly applied in the field of chemistry,life science and biomedical diagnostics.This paper presented an overview on the recent advances in the development and the research progress of fluorescent probes based on the interaction of aptamers and gold nanoparticles. |
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