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| 基于硼氮共掺杂荧光碳点定量分析吡罗昔康 |
| Quantitative Analysis of Piroxicam Based on Boron and Nitrogen Co-doped Fluorescent Carbon Dots |
| 投稿时间：2019-11-15 |
| DOI：10.16018/j.cnki.cn32-1650/n.201904006 |
| 中文关键词: 硼氮共掺杂 碳材料 荧光 吡罗昔康 |
| 英文关键词: boron and nitrogen co-doping carbon material fluorescence piroxicam |
| 基金项目:国家自然科学基金项目(21575123) |
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| 中文摘要: |
| 以邻苯二胺、谷氨酸及硼酸为前驱体，通过简单的一步水热法成功制备水溶性极好的硼氮共掺杂荧光碳点(B，N-CDs)。该B，N-CDs粒径约为20 nm，在吡罗昔康(PRX)的存在下，由于B，N-CDs和PRX之间存在强烈的电子或能量转移导致发生了强烈的荧光淬灭效应。据此，应用荧光碳点B，N-CDs作为荧光探针成功构建了高选择性、高灵敏性的PRX检测荧光传感器。实验数据显示，该传感器具有响应速度快、线性范围宽和检测限低等优点。检测PRX的线性范围为2×10-5~1.5×10-4 mol/L，LOD为5.7×10-8 mol/L。该传感器用于实际样品检测得到了较好的回收率(94.3%~103.3%)，充分说明B，N-CDs在药物检测领域具有很好的潜在应用价值。 |
| 英文摘要: |
| Using o-phenylenediamine, glutamic acid and boric acid as precursors, B, N-CDs with excellent water solubility were successfully prepared by a simple one-step hydrothermal method. The particle size of B, n-CdS is about 20 nm. In the presence of piroxicam(PRX), strong electron or energy transfer between B, N-CDs and PRX results in strong fluorescence quenching effect. Based on this, a highly selective and sensitive PRX fluorescent sensor was successfully constructed by using fluorescent carbon point B, N-CDs as fluorescent probes. Experimental data show that the sensor has the advantages of fast response, wide linear range and low detection limit. The linear range of PRX was 2×10-5~1. 5×10-4 mol/L and LOD was 5. 7×10-8 mol/L. The sensor has a good recovery rate(94. 3% ~ 103. 3%)in the actual sample detection, which fully shows that B, N-CDs has a good potential application value in the field of drug detection. |
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