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| 基于单壁碳纳米管修饰电极测定贝诺酯片剂中贝诺酯的含量 |
| Determination of Benorilate in Benorilate Tablets by Single-wall Carbon Nanotube-modified Electrode |
| 投稿时间：2015-09-12 |
| DOI：10.16018/j.cnki.cn32-1650/n.201504001 |
| 中文关键词: 单壁碳纳米管 贝诺酯 化学修饰电极 电化学测定 |
| 英文关键词: Single-wall carbon nanotube Benorilate Chemically modified electrode Electrochemical determination |
| 基金项目:浙江省哲学社会科学重点研究基地项目(江南文化研究中心)(15JDJN02YB) |
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| 中文摘要: |
| 运用循环伏安法研究了贝诺酯在单壁碳纳米管修饰电极上的电化学行为。在B-R缓冲溶液(pH 5.0)中，贝诺酯于1.10 V( vs. SCE)电位处有一个峰形很好的氧化峰。与裸玻碳电极相比，贝诺酯在修饰电极上的电位正移了约30 mV，峰电流增加了近5倍。在最佳的实验条件下，贝诺酯的氧化峰电流与其浓度(2.8×10-6~1.4×10-4 mol/L)呈现出良好的线性关系，检出限为4.8×10-7 mol/L。该方法用于实际样品贝诺酯片剂的检测中，结果令人满意。 |
| 英文摘要: |
| The electrochemical behaviors of benorilate at single-wall carbon nanotabes(SWNTs)-modified glassy carbon electrode(GCE)have been investigated by cyclic voltammetry. At the SWNTs-modified GCE, benorilate yields a well-defined oxidation peak at 1. 10 V(vs. SCE)in a Britton-Robinson(B-R)buffer solution(pH 5. 0). Compared with the bare GCE, the peak potential shifted positively about 30 mV, and the peak current increased 5 times. Under the optimal conditions, the oxidation peak current of benorilate is linear with its concentration in the range of 2. 8×10-6~1. 4×10-4 mol/L, and the detection limit is 4. 8×10-7 mol/L. The proposed method has been applied to the determination of benorilate in drug tablets, and the results are satisfied. |
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