| In order to improve the solubility and dissolution rate of carvedilol, the solid dispersion technology is used, through the solvent method, and PVP K30 is used as the carrier, the drug assisted mass ratio(CAR∶PVP K30), the amount of solvent and the temperature of solvent evaporation are selected as tested factors, orthogonal test method is used to obtain the optimum process for the preparation of carvedilol solid dispersion system: The mass ratio of drug and carrier material is 1∶9, adding 10 mL anhydrous ethanol, and the temperature of evaporation solvent is 50 ℃. Compared with the carvedilol API, the solid dispersion of carvedilol prepared by the best process has a 29-fold increase in solubility, and the percentage of dissolution after 60 min increases from below 16. 25% to 98. 04%. |